吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
无码免费人妻A片AAA毛片一区,成人试看120秒体验区,处破女轻点疼丨98分钟
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-MEF2C(Thr20)/Gold Conjugated antibody (bs-5482R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5482R-Gold
英文名稱1 Rabbit Anti-phospho-MEF2C(Thr20)/Gold Conjugated antibody
中文名稱 膠體金標記的磷酸化肌細胞增強因子2C抗體
別    名 MEF2C(phospho T20); MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C); Myocyte enhancer factor 2C; Myocyte specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C; MEF2C_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  細胞生物  免疫學  染色質(zhì)和核信號  神經(jīng)生物學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEF2C around the phosphorylation site of Thr20
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.

Function:
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. Interacts with MYOCD (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain and skeletal muscle.

Post-translational modifications:
Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.
Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.
Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.
Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

DISEASE:
Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

Database links:

Entrez Gene: 512254 Cow

Entrez Gene: 4208 Human

Entrez Gene: 17260 Mouse

Entrez Gene: 733590 Pig

Entrez Gene: 499497 Rat

Omim: 600662 Human

SwissProt: Q2KIA0 Cow

SwissProt: Q06413 Human

SwissProt: Q8CFN5 Mouse

SwissProt: A4UTP7 Pig

Unigene: 649965 Human

Unigene: 24001 Mouse

Unigene: 451574 Mouse

Unigene: 484098 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
风流老熟女一区二区三区| 亚洲爆乳精品无码一区二区三区| 高H猛烈失禁潮喷A片在线观看| 免费看人妻换人妻互换A片爽| 丰满少妇张开大白腿| 纯爱无遮挡H肉动漫在线播放| 亚洲AV天堂AV在线成人播放| 国产AV人人夜夜澡人人爽麻豆 | 年轻18GAY白嫩青少年| 成人无遮挡18禁免费视频| 国产婷婷色一区二区三区在线| 日本在线观看| 欲求不満の人妻松下纱荣子| 大SAO奶涨奶头痒快来吃| 动漫3D成人H无码国漫| 18禁裸乳无遮挡啪啪无码免费| 肉乳乱无码A片观看免费| 色综合久久无码五十路人妻| 精品无人区无码乱码毛片国产| 2022最新韩国理伦片在线观看| 丁香花在线观看免费观看图片| 丁香婷婷综合激情五月色| 欧美熟妇XXXXX欧美老妇不卡 | 亚洲AV无码一区二区三区网址 | 国产特级毛片A片WWW| 无码高潮少妇毛多水多水免费| zzijzzij亚洲日本少妇jizjiz | GOGO人体| 亚洲人成色777777精品音频| 国产肉体XXXX裸体137大胆| 欧美顶级少妇做爰HD| 国产情侣一区二区| 亚洲日本无码一区二区三区四区卡| 国产999精品久久久久久| 99精产国品一二三产区| 日本巜侵犯人妻人伦| 欧美性色黄大片A级毛片视频| 无码AV中文字幕久久专区| 全黄裸片一29分钟免费真人版| 成熟女人毛片WWW免费版在线| 狠狠色噜噜狠狠狠888米奇视频 |