吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲AV午夜成人片精品网站,欧美午夜精品久久久久久浪潮
Rabbit Anti-phospho-MEF2C(Thr300)/Cy7 Conjugated antibody (bs-5483R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-5483R-Cy7
英文名稱1 Rabbit Anti-phospho-MEF2C(Thr300)/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的磷酸化肌細(xì)胞增強(qiáng)因子2C抗體
別    名 MEF2C(phospho T300); MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C); Myocyte enhancer factor 2C; Myocyte specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C; MEF2C_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEF2C around the phosphorylation site of Thr300
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.

Function:
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. Interacts with MYOCD (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain and skeletal muscle.

Post-translational modifications:
Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.
Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.
Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.
Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

DISEASE:
Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

Database links:

Entrez Gene: 512254 Cow

Entrez Gene: 4208 Human

Entrez Gene: 17260 Mouse

Entrez Gene: 733590 Pig

Entrez Gene: 499497 Rat

Omim: 600662 Human

SwissProt: Q2KIA0 Cow

SwissProt: Q06413 Human

SwissProt: Q8CFN5 Mouse

SwissProt: A4UTP7 Pig

Unigene: 649965 Human

Unigene: 24001 Mouse

Unigene: 451574 Mouse

Unigene: 484098 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
成人免费视频一区二区| 日本少妇春药特殊按摩3| 手机电影网站| 啦啦啦高清影视在线观看视频| 永久免费AV无码网站性色AV| 亚洲久热无码AV中文字幕| 欧美黑人又粗又大久久久| 宅男视频| 99精品国产一区二区| 国产熟妇无码A片AAA毛片视频| 亚洲精品久久无码AV片俺去也| 亚洲色欲色欲WWW在线成人网| 亚洲一区精品无码色成人| 亚洲HAIRY多毛PICS大全| 色一情一区二区三区四区| 无码久久久久久久久| 无码少妇高潮浪潮AV久久| 一个人看的WWW片免费高清中文| 人妻无码中文字幕免费视频蜜桃| AAA级久久久精品无码片| 无码人妻一区二区三区在线视频| 日韩AV无码中文字幕| 8AV国产精品爽爽ⅤA在线观看| 无码人妻精品一区二区蜜桃网站| 免费看国产曰批40分钟| 日韩欧美一区二区三区免费观看| 国产精品videossex国产高清| 鸡西市天气预报| A级毛片在线观看| 精品无码一区二区三区爱欲| 99久久精品费精品蜜臀AV| 中文字幕AV一区二区三区| 亚洲色偷偷综合亚洲AV78| 色多多app| 国产精品无码AV无码| 人妻少妇被猛烈进入中文字幕 | 亚洲 小说 欧美 激情 另类| 全国最大成人网站| 一本一道久久综合狠狠老| 处破女轻点疼丨98分钟| 边做奶水边喷H高H共妻|