吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
一出一进一爽一粗一大视频,实拍各种胸走光见奶头
Rabbit Anti-Phospho-MEF2A(Thr319)/BF555 Conjugated antibody (bs-5485R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5485R-BF555
英文名稱1 Rabbit Anti-Phospho-MEF2A(Thr319)/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的磷酸化肌細胞增強因子2抗體
別    名 MEF2A (phospho T319); p-MEF2A (phospho T319); MEF2A (Phospho-Thr319); MEF2A(phospho T319); myocyte enhancer-binding factor 2; ADCAD1; MADS box transcription enhancer factor 2 polypeptide A; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); MEF 2A; MEF2; MEF2A; Myocyte enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor like protein 1; MEF2A_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 心血管  細胞生物  免疫學(xué)  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEF2A around the phosphorylation site of Thr319
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. MEF2A belongs to a family of DNA binding regulatory proteins. The MEF2 family of transcription factors is highly expressed in the brain when neurons undergo dendritic maturation and synapse formation. MEF2A is especially abundant in granule neurons of the cerebellar cortex throughout the period of synaptogenesis. MEF2A also has key roles in cardiac and skeletal muscle development.

Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.

Subunit:
Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7 (By similarity). Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.

Post-translational modifications:
Constitutive phosphorylation on Ser-408 promotes Lys-403 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-408 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF.
Sumoylation on Lys-403 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-408 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity).
Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

DISEASE:
Defects in MEF2A are a cause of coronary artery disease, autosomal dominant, type 1 (ADCAD1)[MIM:608320]. A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

Database links:

Entrez Gene: 4205 Human

Entrez Gene: 17258 Mouse

Entrez Gene: 309957 Rat

Omim: 600660 Human

SwissProt: Q02078 Human

SwissProt: Q60929 Mouse

SwissProt: Q2MJT0 Rat

Unigene: 268675 Human

Unigene: 132788 Mouse

Unigene: 426509 Mouse

Unigene: 466976 Mouse

Unigene: 162435 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MEF2是一種主要存在于肌細胞的轉(zhuǎn)錄因子,近來研究發(fā)現(xiàn)他也存在于肝臟,并且其表達及活性增加可能激活HSC,提高Ⅰ型膠原啟動子的活性及刺激HSC的增生. 因此,MEF2可能在肝纖維化的發(fā)生,發(fā)展中發(fā)揮著重要作用。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
天天躁日日躁狠狠躁AV中文| 鲁一鲁一鲁一鲁一澡| 亚洲国产高清国产拍精品| 国模小黎自慰GOGO人体| 亚洲AV无码乱码国产麻豆| 中国极品少妇XXXXX| 亚洲色偷偷综合亚洲AV78| 成人区色情综合小说| 办公室丰满秘书BD正在播放| 人善交VIDEOS欧美3D| 大白肥妇BBVBBW高潮| 国产又爽又猛又粗的视频A片| 中文字幕亚洲无线码在线一区| 国产精品美女WWW爽爽爽视频| 狠狠综合久久AV一区二区| 爆乳熟妇一区二区三区| 99热久久这里只精品国产WWW| 国产熟女一区二区三区五月婷| 粗大挺进朋友人妻身体里国产电影 | 国产精品第一页| 18禁男女爽爽爽午夜网站免费| 国产SM主人调教女M视频| 性久久久久久久| 娇妻借朋友高H繁交H| 天堂资源最新在线| 国产乱子伦精品无码专区| 亚洲欧美自偷自拍另类小说| 久久www香蕉免费人成| 免费A级毛片无码无遮挡| 国产真人无码作爱视频免费| 午夜精品久久久久久毛片| 久久久无码精品亚洲日韩啪啪网站| 国产无遮挡吃胸膜奶免费看| 日韩A片无码毛片免费看小说 | 日本少妇被爽到高潮无码| 亚洲AV无码乱码国产麻豆| 乱人伦XXXX国语对白| JAPAN少妇洗澡VIDEOS| 波多野结衣电影| 男女猛烈激情XX00免费视频| 97精品国产一区二区三区|