吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
中文字幕高清免费日韩视频在线,欧美激情精品久久久久久 ,国产亚洲精品久久久无码
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-NDEL1(Ser242)/BF488 Conjugated antibody (bs-5523R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5523R-BF488
英文名稱1 Rabbit Anti-phospho-NDEL1(Ser242)/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸化中心粒蛋白Nudel抗體
別    名 NDEL1(phospho S242); Nudel(p-Ser242); A. nidulans; DKFZp451M0318; ENDOOLIGOPEPTIDASE A; EOPA; MITAP 1; MITAP1; Mitosin associated protein 1; Mitosin associated protein MITAP1; Mitosin-associated protein 1; Ndel 1; Ndel1; NDEL1_HUMAN; Nuclear distribution gene E like homolog 1; Nuclear distribution protein nudE like 1; Nuclear distribution protein nudE-like 1; NUDE like protein; NudE nuclear distribution gene E homolog like 1 A. nidulans; NudE nuclear distribution gene E homolog like 1; NUDEL; Protein Nudel.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NDEL1 around the phosphorylation site of Ser242
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Nudel is important for normal cortical development. It is invovled in microtubule organization, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50% identity with mouse and human NUDE proteins.

Function:
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Subunit:
Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.

Tissue Specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Post-translational modifications:
Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.
Palmitoylation at Cys-273 reduces affinity for dynein.

Similarity:
Belongs to the nudE family.

Database links:

Entrez Gene: 81565 Human

Entrez Gene: 83431 Mouse

Entrez Gene: 170845 Rat

Omim: 607538 Human

SwissProt: Q9GZM8 Human

SwissProt: Q9ERR1 Mouse

SwissProt: Q78PB6 Rat

Unigene: 372123 Human

Unigene: 31979 Mouse

Unigene: 2947 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

中心粒蛋白Nudel是動物細胞中,中心體微管組織的主要細胞器,是細胞質(zhì)動力蛋白調(diào)節(jié)因子在中心體組裝及徽管組織中發(fā)揮重要作用。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
狠狠躁18三区二区一区| 机长脔到她哭H粗话H动漫| 亚洲一区精品无码色成人| 国产福利视频| 久久久久99精品成人片| 国产成人一区二区三区影| 日本强好片久久久久久AAA| 国产人妖乱国产精品人妖| 精品国产成人亚洲午夜福利| 天堂8在线天堂资源BT| 久久精品国产一区二区电影| 亚洲AV色香蕉一区二区三区| 琪琪婷婷五月色综合久久| 国产乱子伦农村叉叉叉| 97精品国产手机| 天天躁日日躁狠狠躁| 无码人妻精品一区二区三区久久久| 无码精品人妻一区二区三区漫画| 天堂√最新版中文在线| 中文字幕欧美人妻精品一区| 欧美大片VA欧美在线播放| 国产无遮挡A片又黄又爽| 啊灬啊灬啊灬免费毛片| 国产精品亚洲一区二区三区| 国产欧美精品区一区二区三区| 嗯快点别停舒服好爽受不了了| 久久久久亚洲AV无码专区体验| 国产精品美女午夜爽爽爽免费| 成人做受视频试看60秒| 国产99在线 | 亚洲| 闺蜜男友猛撞H花液H深| 欧美亚洲色综久久精品国产| 影音先锋资源站| 久久99精品久久久久婷婷| 国产AV无码专区亚洲A∨毛片| 最近高清中文在线字幕在线观看| 美国СЕКС| 亚洲女人被黑人巨大进入| 777午夜精品久久AV蜜臀| 小12箩利洗澡无码视频网站| 欧美乱妇日本无乱码特黄大片 |