吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯(lián)系我們
亚洲女人被黑人巨大进入,琪琪婷婷五月色综合久久
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Tuberin(Ser1418)/PE-Cy3 Conjugated antibody (bs-5612R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5612R-PE-Cy3
英文名稱1 Rabbit Anti-Phospho-Tuberin(Ser1418)/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的磷酸化結節(jié)性硬化蛋白抗體
別    名 TSC2(phospho S1410); Tuberin (Phospho Ser1410); Tuberin (Phospho S1410); Phospho-TSC2 (Ser1410); P-Tuberin/TSC2 (Ser1410); P-TSC2 (Ser1410); FLJ43106; LAM; TSC2; TSC2_HUMAN; TSC4; Tuberin; Tuberous sclerosis 2 protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  神經生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 200kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1418
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

Function:
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Subunit:
Interacts with TSC1 and HERC1; the interaction with TSC1 stabilizes TSC2 and prevents the interaction with HERC1. May also interact with the adapter molecule RABEP1. The final complex contains TSC2 and RABEP1 linked to RAB5 (Probable). Interacts with HSPA1 and HSPA8. Interacts with DAPK1.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.

Tissue Specificity:
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Post-translational modifications:
Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1. Phosphorylation at Ser-939 and Thr-1462 by PKB/AKT1 is induced by growth factor stimulation. Phosphorylation by AMPK activates it and leads to negatively regulates the mTORC1 complex. Phosphorylated at Ser-1798 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling. Phosphorylated by DAPK1.

DISEASE:
Defects in TSC2 are the cause of tuberous sclerosis type 2 (TSC2) [MIM:613254]. TSC2 is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. It is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes.
Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.

Similarity:
Contains 1 Rap-GAP domain.

Database links:

Entrez Gene: 7249 Human

Entrez Gene: 22084 Mouse

Entrez Gene: 24855 Rat

Omim: 191092 Human

SwissProt: P49815 Human

SwissProt: Q61037 Mouse

SwissProt: P49816 Rat

Unigene: 90303 Human

Unigene: 30435 Mouse

Unigene: 5875 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Tuberin 為180kD-220的蛋白產生于結節(jié)性硬化(TSC-2)位于染色體16的基因。結節(jié)性硬化為常染色體疾病已知為斑痣性錯構瘤病其特征為廣泛性發(fā)展呈良性生長,在許多組織與器官中描述為錯構瘤。Tuberin被認為在GTPase活動性蛋白中起作用調節(jié)細胞內吞與作為腫瘤抑制子。Tuberin低水平廣泛性表達在大多數(shù)組織中,而在皮層神經元、小腦浦肯野氏細胞、脊索運動神經元、胰島B細胞、心肌、腎臟與皮膚的小血管中表達增加。
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
日韩三级| 边摸边脱吃奶边高潮视频免费| 亚洲大码熟女在线观看| 国模少妇一区二区三区| 中文无码人妻有码人妻中文字幕 | 厨房掀起少妇裙子挺进去| 99国产精品久久久久久久成人热 | 女厕厕露P撒尿八个少妇| 亚洲欧美一区二区三区在线| 久久久久免费毛A片免费一瓶梅 | 精品一二三区久久AAA片| 日韩精品久久久久久久电影蜜臀| 成人欧美一区二区三区黑人| 色一情一乱一伦| 久久人妻熟女一区二区| 久久久久久AV无码免费网站下载| 制服丝袜中文字幕在线 | 久久精品国产亚洲AV无码娇色| 色哟哟网站入口在线观看视频 | 少妇高潮一区二区三区99| 两个黑人大战嫩白金发美女| 女人张开腿让男人桶爽| 亚洲AV国产爽歪歪无码| 嗯灬啊灬把腿张开灬A片小说| 和尚吮她的花蒂和奶水视频| 国产AV国片偷人妻麻豆| 久久国产加勒比精品无码| 野花香视频在线观看免费高清版| 国产一区二区三区| 久久人妻无码毛片A片麻豆 | 天天干天天射天天操| 国产又黄又大又粗的视频| 少妇高潮抽搐无码AV久久| 曰本无码人妻丰满熟妇啪啪| 国产农村熟妇出轨VIDEOS| 国产精品99久久免费观看| 天天躁日日躁AAAAXXXX| 中文字幕在线观看| 波多野结AV衣东京热无码专区| 日韩精品无码中文字幕一区二区| 啊灬啊灬啊灬快灬高潮少妇A片|