吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲 小说 欧美 激情 另类,亚洲精品无码高潮喷水在线,亚洲AV无码国产一区二区三区
Rabbit Anti-Phospho-Tuberin(Ser1418)/BF488 Conjugated antibody (bs-5612R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5612R-BF488
英文名稱1 Rabbit Anti-Phospho-Tuberin(Ser1418)/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的磷酸化結(jié)節(jié)性硬化蛋白抗體
別    名 TSC2(phospho S1410); Tuberin (Phospho Ser1410); Tuberin (Phospho S1410); Phospho-TSC2 (Ser1410); P-Tuberin/TSC2 (Ser1410); P-TSC2 (Ser1410); FLJ43106; LAM; TSC2; TSC2_HUMAN; TSC4; Tuberin; Tuberous sclerosis 2 protein.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 200kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1418
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

Function:
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Subunit:
Interacts with TSC1 and HERC1; the interaction with TSC1 stabilizes TSC2 and prevents the interaction with HERC1. May also interact with the adapter molecule RABEP1. The final complex contains TSC2 and RABEP1 linked to RAB5 (Probable). Interacts with HSPA1 and HSPA8. Interacts with DAPK1.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.

Tissue Specificity:
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Post-translational modifications:
Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1. Phosphorylation at Ser-939 and Thr-1462 by PKB/AKT1 is induced by growth factor stimulation. Phosphorylation by AMPK activates it and leads to negatively regulates the mTORC1 complex. Phosphorylated at Ser-1798 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling. Phosphorylated by DAPK1.

DISEASE:
Defects in TSC2 are the cause of tuberous sclerosis type 2 (TSC2) [MIM:613254]. TSC2 is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. It is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes.
Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.

Similarity:
Contains 1 Rap-GAP domain.

Database links:

Entrez Gene: 7249 Human

Entrez Gene: 22084 Mouse

Entrez Gene: 24855 Rat

Omim: 191092 Human

SwissProt: P49815 Human

SwissProt: Q61037 Mouse

SwissProt: P49816 Rat

Unigene: 90303 Human

Unigene: 30435 Mouse

Unigene: 5875 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Tuberin 為180kD-220的蛋白產(chǎn)生于結(jié)節(jié)性硬化(TSC-2)位于染色體16的基因。結(jié)節(jié)性硬化為常染色體疾病已知為斑痣性錯(cuò)構(gòu)瘤病其特征為廣泛性發(fā)展呈良性生長(zhǎng),在許多組織與器官中描述為錯(cuò)構(gòu)瘤。Tuberin被認(rèn)為在GTPase活動(dòng)性蛋白中起作用調(diào)節(jié)細(xì)胞內(nèi)吞與作為腫瘤抑制子。Tuberin低水平廣泛性表達(dá)在大多數(shù)組織中,而在皮層神經(jīng)元、小腦浦肯野氏細(xì)胞、脊索運(yùn)動(dòng)神經(jīng)元、胰島B細(xì)胞、心肌、腎臟與皮膚的小血管中表達(dá)增加。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
在线观看的av网站| 亚洲日韩精品欧美一区二区| 久久精品国产亚洲AV久| A片做爰片仑理片免费看午夜蝴蝶| 色国产精品一区在线观看| 国产97在线 | 亚洲| 女朋友水太多进去就软了| 久久久久亚洲AV无码网站 | 将军脔到她哭H粗话H| 亚洲AV日韩AV无码AV| 国产偷抇久久精品A片69| 欧美一区二区三区啪啪| 亚洲色成人网站WWW永久四虎| 高清视频在线观看| 国产精品国产三级国产A| 免费看人妻换人妻互换A片爽| 色婷婷综合久久久久中文一区二区| 99久久国产综合精品麻豆| 亚洲精品AV中文字幕在线| 无码一区二区三区| 精品国模一区二区三区| 国产午夜三级一区二区三| 亚洲国产精品日韩AV不卡在线| 国产69久久精品成人看| 国产精品沙发午睡系列990531| 亚洲国产精品尤物YW在线观看| の教室の成熟した女教师| 最近免费中文字幕中文高清百度| 樱桃视频大全免费高清版| 亚洲∧V久久久无码精品| 人妻少妇偷人精品无码| 久久精品亚洲一区二区三区浴池| 吃奶呻吟打开双腿做受动态图 | 97精品人妻一区二区三区香蕉| 国产成人精品一区二区三区无码| 久久久欧美精品激情| 无码久久精品国产亚洲AV影片| 欧美巨大另类极品videosbest | 国产又粗又猛又爽又黄| 美女高潮黄又色高清视频免费| 亚洲AV国产爽歪歪无码|