| 產(chǎn)品編號(hào) | bsm-2141M-BF488 |
| 英文名稱1 | Mouse Anti-CRIPTO/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的畸胎瘤衍化生長(zhǎng)因子單克隆抗體(C端) |
| 別 名 | CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-like cripto protein CR1; TDGF 1; TDGF-1; TDGF1; Teratocarcinoma derived growth factor 1; Teratocarcinoma-derived growth factor 1; teratocarcinoma-derived growth factor 1 isoform 1 precursor; TDGF1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | 2B11 |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 13kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Teratocarcinoma-derived growth factor 1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Subunit: Interacts with the activin type-1 receptor ACVR1B. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Similarity: Contains 1 EGF-like domain. Database links: Entrez Gene: 6997 Human Entrez Gene: 21667 Mouse Omim: 187395 Human SwissProt: P13385 Human SwissProt: P51865 Mouse Unigene: 385870 Human Unigene: 5090 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Cripto-1是表皮生長(zhǎng)因子-Cripto-FRL-Criptic(EGF-CFC)家族成員之一, 屬于轉(zhuǎn)化生長(zhǎng)細(xì)胞TGF-β蛋白家族及Nodal蛋白質(zhì)的共同受體。Cripto蛋白對(duì)于胚胎的發(fā)育占有非常重要的地位。 Cripto-1在人類的多種腫瘤如結(jié)腸癌、乳腺癌、卵巢癌、胰腺癌等中高表達(dá)，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信號(hào)通路,介導(dǎo)細(xì)胞增殖和抑制細(xì)胞凋亡，Cripto蛋白的單細(xì)胞繁殖抗體，可以有效抑制一些癌細(xì)胞的生長(zhǎng)。 |
