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Rabbit Anti-FGFR1OP/FITC Conjugated antibody (bs-5712R-FITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5712R-FITC
英文名稱1 Rabbit Anti-FGFR1OP/FITC Conjugated antibody
中文名稱 FITC標記的成纖維細胞生長因子受體1原癌基因伴侶蛋白抗體
別    名 FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGFR1OP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.

Function:
Required for anchoring microtubules to the centrosomes.

Subunit:
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.

Tissue Specificity:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.

DISEASE:
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.

Similarity:
Belongs to the FGFR1OP family.
Contains 1 LisH domain.

Database links:

Entrez Gene: 11116 Human

Entrez Gene: 75296 Mouse

Entrez Gene: 365103 Rat

Entrez Gene: 683722 Rat

Omim: 605392 Human

SwissProt: Human

SwissProt: O95684 Human

SwissProt: Q66JX5 Mouse

SwissProt: Q4V7C1 Rat

Unigene: 487175 Human

Unigene: 227250 Mouse

Unigene: 166829 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FGFR1OP蛋白最初是在引起干細胞骨髓增生病的癌蛋白中作為FGFR1的融合伴侶被發(fā)現的,目前研究認為,FGFR1OP蛋白在很多組織細胞中都有不同的存在,尤其是以腦, 心,肝,肌肉,腎,小腸,結腸,腎上腺,前列腺,睪丸和胰腺中高表達。
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