| 產(chǎn)品編號(hào) | bs-6027R-BF488 |
| 英文名稱1 | Rabbit Anti-CADM3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的細(xì)胞粘附分子3抗體 |
| 別 名 | Brain immunoglobulin receptor; Synaptic cell adhesion molecule 3; Necl 1; synCAM3; CADM 3; Cell adhesion molecule 3; FLJ10698; IGSF4B; Immunoglobulin superfamily member 4B; NECL1; Nectin like protein 1; TSLC1 like protein 1; TSLL1; CADM3_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CADM3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Immunoglobulin superfamily member 4B (Cell adhesion molecule 3, Nectin-like protein 1) is a nectin family gene product that contains 2 Ig-like C2-type (immunoglobulin-like) domains and an Ig-like V-type (immunoglobulin-like) domain. IGSF4B is a single-pass type I membrane protein that localizes to cell-cell interacting sites along the plasma membrane. IGSF4B functions as a cell adhesion molecule at cell-cell junctions. IGSF4B can be found as a homodimer and has a dual calcium-independent adhesion function; a homophilic cell-cell interaction and a heterophilic cell-cell interaction involving IGSF4, Nectin 1 and Nectin 3. IGSF4B may also interact with EPB41L1 which has a potential for regulating structure or function of cell-cell junctions By similarity. Isoform 1 is expressed in adult and fetal brain. Isoform 2 is highly expressed in the cerebellum but is also weakly expressed in placenta. IGSF4B has been found to be markedly over-expressed in glioma cell lines and prostate cancer cell lines. Function: Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Subunit: Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK. Subcellular Location: Cell junction. Cell membrane. Localized at the cell-cell attached sites of the plasma membrane. Tissue Specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. Similarity: Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 57863 Human Entrez Gene: 94332 Mouse Omim: 609743 Human SwissProt: Q8N126 Human SwissProt: Q99N28 Mouse Unigene: 365689 Human Unigene: 330524 Mouse Unigene: 138884 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
