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Rabbit Anti-CABP4/AP Conjugated antibody (bs-11980R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11980R-AP
英文名稱1 Rabbit Anti-CABP4/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的瞬時受體電位通道蛋白4抗體
別    名 CABP 4; CaBP4; CABP4_HUMAN; Calcium binding protein 4; Calcium-binding protein 4; CSNB 2B; CSNB2B.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經(jīng)生物學  信號轉導  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Cow, Sheep, )
產(chǎn)品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 111kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPC5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The calcium binding protein (CaBP) family shares much similarity to calmodulin. It has been shown that CaBP proteins can substitute functionally for, and probably augment the function of, calmodulin. Calcium binding proteins are a crucial part of calcium mediated cellular signal transduction in the central nervous system. There are several members of the family with varying expression patterns. CaBP1 and CaBP2 can be expressed as multiple, alternatively spliced variants in brain and retina. CaBP3, CaBP4 and CaBP 5 are restricted to retinal rod and cone cells.

Function:
Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.

Subcellular Location:
Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.Target information above from: UniProt accession P57796 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010). Information by UniProt

Tissue Specificity:
Expressed in retina and in the inner hair cells (IHC) of the cochlea.

Post-translational modifications:
Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity.

DISEASE:
Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.

Similarity:
Contains 4 EF-hand domains.

Database links:

Entrez Gene: 57010 Human

Entrez Gene: 73660 Mouse

Entrez Gene: 365394 Rat

Omim: 608965 Human

SwissProt: P57796 Human

SwissProt: Q8VHC5 Mouse

Unigene: 143036 Human

Unigene: 379226 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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