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Rabbit Anti-Glycine Receptor alpha 1 + alpha 2/APC Conjugated antibody (bs-12090R-APC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12090R-APC
英文名稱1 Rabbit Anti-Glycine Receptor alpha 1 + alpha 2/APC Conjugated antibody
中文名稱 APC標(biāo)記的甘氨酸受體α1+甘氨酸受體α2抗體
別    名 GLRA1+GLRA2; GLRA1; GLRA2; Glycine receptor 48 kDa subunit; Glycine receptor alpha 1; Glycine receptor alpha 2; Glycine receptor subunit alpha 1; Glycine receptor subunit alpha 2; Glycine receptor, alpha 1 subunit; Glycine receptor, alpha 2 subunit; STHE; GLRA1_HUMAN; GLRA2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Glycine Receptor alpha 1 + alpha 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.

Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Subunit:
Pentamer composed of alpha and beta subunits.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

DISEASE:
Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.

Database links:

Entrez Gene: 2741 Human

Entrez Gene: 2742 Human

Entrez Gene: 14654 Mouse

Entrez Gene: 237213 Mouse

Entrez Gene: 24397 Rat

Entrez Gene: 25674 Rat

Omim: 138491 Human

Omim: 305990 Human

SwissProt: P23415 Human

SwissProt: P23416 Human

SwissProt: Q6DJV9 Human

SwissProt: Q64018 Mouse

SwissProt: Q7TNC8 Mouse

SwissProt: P07727 Rat

SwissProt: P22771 Rat

Unigene: 121490 Human

Unigene: 2700 Human

Unigene: 113877 Mouse

Unigene: 358598 Mouse

Unigene: 10109 Rat

Unigene: 10379 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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