| 產(chǎn)品編號(hào) | bs-13946R-AP |
| 英文名稱1 | Rabbit Anti-CHTF18/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的16號(hào)染色體開(kāi)放閱讀框41抗體 |
| 別 名 | C16orf41; 6030457M03Rik; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Chromosome transmission fidelity protein 18 homolog; chtf18; Ctf18; CTF18_HUMAN; hCTF18; MGC38008; RUVBL. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞周期蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 106kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CHTF18/C16orf41 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CTF18 is a 975 amino acid protein encoded by the human gene CHTF18. CTF18 is a protein that is structurally related to the Rad24 and RFC (replication factor C) proteins. CTF18 is believed to form a novel RFC complex and functions redundantly with Rad24 in the DNA replication block checkpoint. The CTF18-RFC complex is a seven-subunit structure that consists of the four small subunits of RFC, together with CTF18, DCC1, and CTF8. This RFC complex is responsible for loading the replication clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA and functions in DNA replication and repair. Regulated unloading of PCNA during the progression and termination of DNA replication does not seem to be a function of the CTF18-RFC complex. Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Subcellular Location: Nucleus. Associates with chromatin during S phase. Similarity: Belongs to the activator 1 small subunits family. CTF18 subfamily. Database links: Entrez Gene: 63922 Human SwissProt: Q8WVB6 Human SwissProt: Q96S08 Human SwissProt: Q9BRG5 Human Unigene: 153850 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
