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Rabbit Anti-ACCN5/BF350 Conjugated antibody (bs-12130R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12130R-BF350
英文名稱1 Rabbit Anti-ACCN5/BF350 Conjugated antibody
中文名稱 BF350標記的小腸鈉通道蛋白5抗體
別    名 amiloride sensitive cation channel 5, intestinal; Amiloride sensitive sodium channel;intestine Na+ channel; amiloride-sensitive cation channel 5; HINAC; INAC; ASIC5_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經生物學  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ACCN5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
ACCN5 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. DEG/ENaC superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Localizing to the cell membrane, ACCN5 is a multi-pass membrane protein that is expressed in small intestine, jejunum and duodenum. ACCN5 is also expressed at low levels in rectum and testis. Existing as a homo- or heterotetramer, ACCN5 functions as a Na+-selective cation channel that, characteristic of its family, can be inhibited by amiloride.

Function:
ACCN5 belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.

Subunit:
Homotrimer or heterotrimer with other ASIC proteins.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.

Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.

Database links:

Entrez Gene: 51802 Human

SwissProt: Q9NY37 Human

Unigene: 381349 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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