吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯系我們
又硬又粗又大一区二区三区视频,A级毛片无码久久精品免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-COP1/Biotin Conjugated antibody (bs-13925R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13925R-Bio
英文名稱1 Rabbit Anti-COP1/Biotin Conjugated antibody
中文名稱 生物素標記的E3泛素蛋白連接酶COP1抗體
別    名 Constitutive photomorphogenesis protein 1 homolog; COP; E3 ubiquitin-protein ligase RFWD2; hCOP1; RFWD2; RFWD2_HUMAN; RNF200; ring finger and WD repeat domain 2; RING finger and WD repeat domain protein 2; RING finger protein 200.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 信號轉導  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human COP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Subcellular Location:
Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.

Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Similarity:
Belongs to the COP1 family.
Contains 1 RING-type zinc finger.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64326 Human

Entrez Gene: 26374 Mouse

Omim: 608067 Human

SwissProt: Q8NHY2 Human

SwissProt: Q9R1A8 Mouse

Unigene: 523744 Human

Unigene: 328135 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.xucheq.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
天天爽夜夜爽夜夜爽精品视频| 好深好湿好硬顶到了好爽| 大胸美女视频| 人妻巨大乳一二三区| 精品国产污污免费网站AⅤ| 99久久99久久免费精品小说| 久久久国产一区二区三区| 亚洲国产精品国自产拍AV| 国产精品久久久久久久久久妞妞 | 成熟女人毛片WWW免费版在线| 无码人妻少妇伦在线电影 | 免费做爰试看120秒| 日本55丰满熟妇厨房伦| 少妇AV射精精品蜜桃专区| 久久精品A亚洲国产V高清不卡| 隔着内裤揉搓她的花蒂H漫画| 精品夜夜爽欧美毛片视频| 13小男生GAY自慰脱裤子| 欧美老妇交乱视频| 国产精品污WWW在线观看| 熟妇人妻VA精品中文字幕| 国产精久久一区二区三区| 粗大挺进朋友人妻身体里国产电影| 两女互摸自慰喷水爽哭直播了| 被黑人猛躁10次高潮视频| 国产99在线 | 欧美| 欧美人妻一区二区三区| 一个刚拔出来另一个| 欧美变态口味重另类在线视频| 人人妻人爽A片二区三区| 亚洲AV无码国产综合专区| 校草喝下春药被男生玩弄| 欧美与黑人午夜性猛交久久久| 精品久久久久久国产| 97人妻精品一区二区三区| 欧美极品JIZZHD欧美| 14妺妺让我破了她的处| 和子发生了性关系的免费视频| 人妻忍着娇喘被中进中出视频| 少妇被又大又粗又爽毛片久久黑人| 无码孕妇孕交在线观看|