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Rabbit Anti-DDOST/RBITC Conjugated antibody (bs-14213R-RBITC)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-14213R-RBITC
英文名稱(chēng)1 Rabbit Anti-DDOST/RBITC Conjugated antibody
中文名稱(chēng) 羅丹明(RBITC)標(biāo)記的晚期糖基化終產(chǎn)物受體1抗體
別    名 Advanced glycation endproduct receptor 1; AGE R1; AGER1; CDG1R; DDOST 48 kDa subunit; Dolichyl diphosphooligosaccharide protein glycosyltransferase subunit (non catalytic); Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Dolichyl-diphosphooligosaccharide-protein glycosyltransferase; EC 2.4.1.119; KIAA0115; MGC2191; OK/SW-cl.45; OKSWcl45; Oligosaccharyl transferase 48 kDa subunit; Oligosaccharyltransferase 48 kDa subunit; Oligosaccharyltransferase subunit 48; OST; OST48; OST48_HUMAN; RP23-25C1.4; WBP1; wu:fa11d01; zgc:66068; zgc:77478.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 免疫學(xué)  糖尿病  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Zebrafish, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DDOST/AGER1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Function:
DDOST (Dolichyl-diphosphooligosaccharide-protein glycosyltransferase) is a component of the oligosaccharyltransferase complex. This complex catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum and co-purifies with ribosomes. DDOST is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.

Subunit:
Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes even after release from the ribosome.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Database links.

DISEASE:
Congenital disorder of glycosylation 1R (CDG1R) [MIM:614507]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the DDOST 48 kDa subunit family.

Database links:

Entrez Gene: 1650 Human

Entrez Gene: 425542 Chicken

Entrez Gene: 510682 Cow

Entrez Gene: 404012 Dog

Entrez Gene: 13200 Mouse

Entrez Gene: 313648 Rat

Entrez Gene: 444283 Xenopus laevis

Entrez Gene: 100145597 Xenopus tropicalis

Entrez Gene: 406408 Zebrafish

Omim: 602202 Human

SwissProt: P48440 Chicken

SwissProt: A6QPY0 Cow

SwissProt: Q05052 Dog

SwissProt: P39656 Human

SwissProt: O54734 Mouse

SwissProt: Q641Y0 Rat

SwissProt: Q6GNR9 Xenopus laevis

SwissProt: B1H3C9 Xenopus tropicalis

SwissProt: Q6NYS8 Zebrafish

Unigene: 523145 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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