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Rabbit Anti-CD35/PE-Cy5 Conjugated antibody (bs-10144R-PE-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10144R-PE-Cy5
英文名稱1 Rabbit Anti-CD35/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的Ⅰ型補(bǔ)體受體抗體(C3b/C4b受體抗體)
別    名 C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  細(xì)胞膜受體  淋巴細(xì)胞  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 274kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CR1/CD35
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

Function:
Mediates cellular binding of particles and immune complexes that have activated complement.

Subunit:
Monomer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Similarity : Belongs to the receptors of complement activation (RCA) family.
Contains 30 Sushi (CCP/SCR) domains.

Database links:

Entrez Gene: 1378 Human

Omim: 120620 Human

SwissProt: P17927 Human

Unigene: 334019 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD35廣泛分布于紅細(xì)胞、粒細(xì)胞、單核細(xì)胞、肥大細(xì)胞、濾泡樹突狀細(xì)胞、腎小球足突細(xì)胞、B細(xì)胞及部分CD4+T細(xì)胞表面.CD35抗原又稱為CR1或者C3b/C4b R,是一種分子量160-250kDa的C3b/C4b補(bǔ)體結(jié)合跨膜蛋白,主要用于濾泡樹突狀細(xì)胞標(biāo)記和濾泡樹突狀細(xì)胞瘤的診斷。
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