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Rabbit Anti-FGFR substrate 3/BF594 Conjugated antibody (bs-10383R-BF594)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-10383R-BF594
英文名稱(chēng)1 Rabbit Anti-FGFR substrate 3/BF594 Conjugated antibody
中文名稱(chēng) BF594標(biāo)記的纖維母細(xì)胞生長(zhǎng)因子受體底物3抗體
別    名 FGFR signalling adaptor SNT2; FGFR substrate 3; Fibroblast growth factor receptor substrate 3; FRS2 beta; FRS2B; FRS3; FRS3 protein; MGC17167; SNT 2; Suc1 associated neurotrophic factor target 2 (FGFR signalling adaptor); Suc1 associated neurotrophic factor target 2; FRS3_HUMAN; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGFR substrate 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008].

Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Subunit:
Binds NTRK1. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.

Similarity:
Contains 1 IRS-type PTB domain.

Database links:

Entrez Gene: 10817 Human

Entrez Gene: 107971 Mouse

Entrez Gene: 316213 Rat

Omim: 607744 Human

SwissProt: O43559 Human

SwissProt: Q91WJ0 Mouse

SwissProt: Q52RG8 Rat

Unigene: 194208 Human

Unigene: 34398 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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