吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
中文人妻熟女乱又乱精品,成人乱码一区二区三区AV
Rabbit Anti-Sumo 2/Gold Conjugated antibody (bs-15494R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-15494R-Gold
英文名稱1 Rabbit Anti-Sumo 2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的泛素樣蛋白Sumo2抗體
別    名 Small ubiquitin-related modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10.9kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sumo 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease

Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Subunit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).

Subcellular Location:
Nucleus. Nucleus, PML body.

Tissue Specificity:
Broadly expressed.

Post-translational modifications:
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.

Similarity:
Belongs to the ubiquitin family. SUMO subfamily.
Contains 1 ubiquitin-like domain.

Database links:

Entrez Gene: 6612 Human

Entrez Gene: 6613 Human

Entrez Gene: 170930 Mouse

Entrez Gene: 20610 Mouse

Entrez Gene: 397044 Pig

Entrez Gene: 499417 Rat

Entrez Gene: 690244 Rat

Omim: 602231 Human

Omim: 603042 Human

SwissProt: P61955 Cow

SwissProt: P55854 Human

SwissProt: P61956 Human

SwissProt: P61957 Mouse

SwissProt: Q9Z172 Mouse

SwissProt: P61958 Pig

SwissProt: P61959 Rat

SwissProt: Q5XIF4 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
无码孕妇孕交在线观看 | 无码国产一区二区三区四区公司| 男女吃奶做爰猛烈紧视频| 国产+高潮+白浆+无码| 一炕四女被窝交换啪啪| 国产传媒果冻天美传媒怎么入职| 久久www香蕉免费人成| 国产精品黄在线观看免费软件| 99精品国产在热久久无码| 亚洲av激情无码专区在线播放| 人妻丰满熟妇AⅤ无码| 狠狠色噜噜狠狠狠狠色综合久 | 免费观看电视剧全集在线播放| 人妻无码ΑV中文字幕久久琪琪布| 久久久亚洲精品无码| 国产精品偷伦视频免费观看了| 杨门十二寡妇肉床艳史电影| 亚洲老熟女@tubeumtv| 亚洲无码在线播放| 精品无码一区二区三区亚洲桃色| 女人高潮真实叫床声MP3| 久久电影网| 日本免费无码一区二区到五区| 国产精品高潮呻吟AV久久动漫| 波多野结衣电影| 日本乱偷中文字幕| 亚洲爆乳无码一区二区三区| 丰满老熟好大BBB| 狠狠色综合7777久夜色撩人| 玩弄丰满少妇高潮A片| 中文字幕乱妇无码AV在线 | 日本护士毛茸茸| 国产,日韩,丝袜,欧美一区| 无码人妻久久一区二区三区不卡| 亚洲国产一区二区A毛片| 年轻漂亮的女教师| 性色AV一区二区三区| 少妇被粗大的猛烈进出免费视频| 国产麻豆精品一区二区三区| 最近免费中文字幕中文高清6 | 少妇久久久久久久久久|