吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产一区二区三精品久久久无广告,中文在线А√天堂官网,亚洲精品无码久久毛片
Rabbit Anti-KAT5 / Tip60/PE-Cy7 Conjugated antibody (bs-13686R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-13686R-PE-Cy7
英文名稱1 Rabbit Anti-KAT5 / Tip60/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的TIP60抗體
別    名 Tip60; 60 kDa Tat interactive protein; 60 kDa Tat-interactive protein; cPLA(2) interacting protein; cPLA(2)-interacting protein; cPLA2; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV1 tat; HIV 1 Tat interactive protein; HIV 1 Tat interactive protein, 60kDa; HIV-1 Tat interactive protein; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; KAT5; KAT5_HUMAN; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KAT5 / Tip60
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Subcellular Location:
Nucleus > nucleolus. Cytoplasm > perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Post-translational modifications:
Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies. Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase.
Phosphorylated form has a higher activity.
Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.

Similarity:
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.

Database links:

Entrez Gene: 10524 Human

Entrez Gene: 81601 Mouse

Entrez Gene: 192218 Rat

Omim: 601409 Human

SwissProt: Q92993 Human

SwissProt: Q8CHK4 Mouse

SwissProt: Q99MK2 Rat

Unigene: 397010 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
CHINESE熟女熟妇1乱| a片在线播放| 人妻含泪让粗大挺进| 无码精品人妻一区二区三区影院 | 一本一道人人妻人人妻αV| 欧美性受xxxx黑人xyx性爽 | 国产精品久久久久无码AV| 精品黑人一区二区三区久久| 尤物视频在线观看| 18禁免费无码无遮挡不卡网站 | 秘书被老板CAO到合不拢腿 | 欧美肥妇BWBWBWBXX| 上司人妻互换HD无码中文字幕 | AV鲁丝一区鲁丝二区鲁丝三区| 野花 高清 中文 免费 日本| 十九岁日本电影免费完整版观看 | 青青草原综合久久大伊人精品| 大肥波BBWWHBBWW| 人人妻人人添人人爽欧美一区| 亚洲欧美一区二区三区在线| 亚洲一码和欧洲二码的尺码区别| 精品人伦一区二区三区蜜桃小说 | 亚洲最大成人网站| 欧美人与性动交CCOO| 精品国产成人亚洲午夜福利 | 久久夜色精品国产| 囯产精品一品二区三区| 成人无码精品1区2区3区免费看| 欧美性激烈粗大精品XXX| 无码性午夜视频在线观看| 日本又色又爽又黄的A片18禁| 日韩AV无码久久一区二区| 亚洲国产精久久久久久久| 国产特级毛片AAAAAAA高清| 国产精品美女久久久久AV爽| 欧美人与物videos另类| 国产偷窥熟女精品视频大全| 水蜜桃AV无码| 无码久久久久久久久| 日韩人妻精品无码一区二区三区| 久久久久亚洲AV片无码|