| 產(chǎn)品編號(hào) | bs-14475R-APC |
| 英文名稱1 | Rabbit Anti-FXYD5/Dysadherin/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的抗粘附素抗體 |
| 別 名 | Dysad; Dysadherin; FXYD 5; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; Fxyd5; FXYD5_HUMAN; FXYD5RIC; HSPC 113; HSPC113; IWU 1; IWU1; KCT 1; KCT1; Keratinocytes associated transmembrane protein 1; OIT 2; OIT2; PRO 6241; PRO6241; RIC. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 腫瘤細(xì)胞生物標(biāo)志物 跨膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dysadherin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Subcellular Location: Membrane. Post-translational modifications: Glycosylated. Similarity: Belongs to the FXYD family. Database links: Entrez Gene: 53827 Human GenBank: NP_054883 Human Omim: 606669 Human SwissProt: Q96DB9 Human Unigene: 333418 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
