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Rabbit Anti-ESF1/PE Conjugated antibody (bs-14634R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-14634R-PE
英文名稱1 Rabbit Anti-ESF1/PE Conjugated antibody
中文名稱 PE標記的ESF1蛋白抗體
別    名 ABT1-associated protein; ABTAP; bA526K24.1; C20orf6; Esf1; ESF1 homolog; ESF1_HUMAN; FLJ20368; HDCMC28P; OTTHUMP00000030301.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  轉運蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ESF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multi-protein complex near the transcription start site by interacting with core promotor elements such as the TATA box, generally located 25-30 base pairs upstream of the transcription start site. ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 forms a complex with ESF1, also designated ABT1-associated protein (ABTAP), which disrupts ABT1 interaction with TBP and suppresses ABT1-induced activation of Pol II-directed transcription. The ABT1/ESF1 complex colocalizes in the nucleolus and nucleoplasm.

Function:
May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1.

Subcellular Location:
Nucleus; nucleolus. Nucleus; nucleoplasm.

Similarity:
Belongs to the ESF1 family.

Database links:

Entrez Gene: 51575 Human

SwissProt: Q9H501 Human

Unigene: 369284 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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