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Rabbit Anti-DNAJC5B/Gold Conjugated antibody (bs-14393R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-14393R-Gold
英文名稱1 Rabbit Anti-DNAJC5B/Gold Conjugated antibody
中文名稱 膠體金標記的DNAJC5B蛋白抗體
別    名 Beta CSP; Beta cysteine string protein; CSP beta; DNJ5B_HUMAN; DnaJ (Hsp40) homolog, subfamily C, member 5 beta; DnaJ homolog subfamily C member 5B; MGC26226.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNAJC5B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The DnaJ family, one of the largest of all the chaperone families, has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat-shock induced proteins are derived from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions that are composed of zinc fingers that form a peptide-binding domain responsible for the chaperone function. They are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC5B is a 199 amino acid protein that contains one J domain and plays an important role in exocytosis. DnaJC5B is expressed in testis where it is tightly bound to lipid membranes. The palmitoylation level of DnaJC5B is thought to correlate with its targeting to specific membranes.

Function:
DnaJ is a testis-specific heat shock protein and functions in association with DnaK(Hsp70). It is a molecular chaperone to facilitate protein folding. DnaJ plays a key role in the chaperone reaction by stimulating the ATPase activity and activating the substrate binding of Hsp70.

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Testis specific.

Post-translational modifications:
Palmitoylated. Palmitoylation is not required for membrane association.

Similarity:
Contains 1 J domain.

Database links:

Entrez Gene: 85479 Human

Entrez Gene: 66326 Mouse

GenBank: NM_033105 Human

SwissProt: Q9UF47 Human

SwissProt: Q9CQ94 Mouse

Unigene: 491885 Human

Unigene: 45615 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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