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Rabbit Anti-DOPEY2/BF488 Conjugated antibody (bs-14410R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-14410R-BF488
英文名稱1 Rabbit Anti-DOPEY2/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的遲鈍蛋白家族2抗體
別    名 21orf5; Dopey-2; C21orf5; DOP2_HUMAN; Dopey family member 2; DOPEY2; homolog of yeast DOP1; Protein dopey-2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)運(yùn)蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 258kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DOPEY2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Dopey-2 is a 2,298 amino acid protein that is ubiquitously expressed with high levels found in the developing central nervous system where it is thought to play a role in protein trafficking between early endosomes and the late Golgi. Multiple isoforms of Dopey-2 exist due to alternative splicing events. The gene encoding Dopey-2 maps to human chromosome 21 and may be involved in the pathogenesis of Down syndrome. The smallest of the human chromosomes, chromosome 21 comprises about 1.5% of the human genome and contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias.

Function:
May be involved in protein traffic between late Golgi and early endosomes.

Tissue Specificity:
Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.

DISEASE:
Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon.

Similarity:
Belongs to the dopey family.

Database links:

Entrez Gene: 9980 Human

Entrez Gene: 70028 Mouse

Omim: 604803 Human

SwissProt: Q9Y3R5 Human

SwissProt: Q3UHQ6 Mouse

Unigene: 204575 Human

Unigene: 23230 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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