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Rabbit Anti-ILF3/APC Conjugated antibody (bs-16604R-APC)
訂購(gòu)熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-16604R-APC
英文名稱1 Rabbit Anti-ILF3/APC Conjugated antibody
中文名稱 APC標(biāo)記的白細(xì)胞介素增強(qiáng)子結(jié)合因子3抗體
別    名 CBTF; Double stranded RNA binding protein 76; Double-stranded RNA-binding protein 76; DRBF; DRBP76; ILF3; ILF3_HUMAN; Interleukin enhancer binding factor 3; Interleukin enhancer-binding factor 3; M phase phosphoprotein 4; M-phase phosphoprotein 4; MPHOSPH4; MPP4; NF AT 90; NF-AT-90; NF110; NF90; NFAR; Nuclear factor associated with dsRNA; Nuclear factor of activated T cells 90 kDa; Nuclear factor of activated T-cells 90 kDa; TCP80; Translational control protein 80  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  轉(zhuǎn)運(yùn)蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ILF3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.

Subcellular Location:
Nucleus; nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by RNA-dependent protein kinase (EIF2AK2).
Methylated by protein arginine N-methyltransferase 1.
Arg-609 is dimethylated, probably to asymmetric dimethylarginine.

Similarity:
Contains 2 DRBM (double-stranded RNA-binding) domains.
Contains 1 DZF domain.

Database links:

Entrez Gene: 3609 Human

Entrez Gene: 614936 Cow

Entrez Gene: 16201 Mouse

Entrez Gene: 84472 Rat

Entrez Gene: 321868 Zebrafish

Omim: 603182 Human

SwissProt: Q12906 Human

SwissProt: Q9Z1X4 Mouse

SwissProt: Q9JIL3 Rat

SwissProt: Q6NXA4 Zebrafish

Unigene: 465885 Human

Unigene: 440026 Mouse

Unigene: 203881 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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