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Rabbit Anti-IRF8/BF594 Conjugated antibody (bs-16704R-BF594)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-16704R-BF594
英文名稱1 Rabbit Anti-IRF8/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的干擾素調(diào)節(jié)因子8抗體
別    名 H ICSBP; H-ICSBP; HGNC:5358; HICSBP; ICSBP 1; ICSBP; ICSBP1; Interferon consensus sequence binding protein 1; Interferon consensus sequence binding protein; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF 8; IRF-8; Irf8; IRF8_HUMAN; MYLS.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  泛素  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRF8
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

Function:
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.

Subcellular Location:
Nucleus.

Tissue Specificity:
Predominantly in lymphoid tissues.

Post-translational modifications:
Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Database links:

Entrez Gene: 3394 Human

Entrez Gene: 396385 Chicken

Entrez Gene: 454294 Chimpanzee

Entrez Gene: 100770390 Chinese Hamster

Entrez Gene: 614909 Cow

Entrez Gene: 489673 Dog

Entrez Gene: 101152979 Gorilla

Entrez Gene: 15900 Mouse

Entrez Gene: 100173775 Orangutan

Entrez Gene: 396645 Pig

Entrez Gene: 100350620 Rabbit

Entrez Gene: 292060 Rat

Entrez Gene: 693933 Rhesus monkey

Omim: 601565 Human

SwissProt: Q90871 Chicken

SwissProt: Q02556 Human

SwissProt: P23611 Mouse

Unigene: 137427 Human

Unigene: 334861 Mouse

Unigene: 228738 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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