| 產(chǎn)品編號 | bs-16909R-APC |
| 英文名稱1 | Rabbit Anti-KCNMB4/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的鈣激活鉀通道蛋白β4抗體 |
| 別 名 | BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated potassium channel subunit beta 4; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-4; Charybdotoxin receptor subunit beta 4; Charybdotoxin receptor subunit beta-4; Hbeta4; K(VCA)beta 4; K(VCA)beta-4; KCMB4_HUMAN; KCNMB 4; Kcnmb4; Large conductance calcium dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta 4; Maxi K channel subunit beta-4; Potassium large conductance calcium activated channel subfamily M beta member 4; Slo beta 4; Slo-beta-4; subfamily M subunit beta-4. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KCNMB4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008] Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. Post-translational modifications: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin. Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily. Database links: Entrez Gene: 27345 Human Entrez Gene: 58802 Mouse Omim: 605223 Human SwissProt: Q86W47 Human SwissProt: Q9JIN6 Mouse Unigene: 525529 Human Unigene: 440652 Mouse Unigene: 162953 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
