| 產(chǎn)品編號 | bs-17157R-BF488 |
| 英文名稱1 | Rabbit Anti-Tropomodulin 4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的原肌球蛋白調(diào)節(jié)蛋白4抗體 |
| 別 名 | Actin capping protein; SK TMOD; Sk-Tmod; Skeletal muscle tropomodulin; SKTMOD; TMOD 4; TMOD4; Tropomodulin 4 (muscle); Tropomodulin-4. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導(dǎo) 結(jié)合蛋白 細胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Tropomodulin 4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments (1,2). A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments (3,4). Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans (2). TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively (5). TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 (1). The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein (1,5). The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B (5). Function: Tropomodulin 4 prevents the elongation and depolymerization of the actin filaments at the pointed end, and intervenes in the formation of the short actin protofilament, which determines the structure of the membrane skeleton. Subunit: Binds to the N-terminus of tropomyosin and to actin. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Highly expressed in skeletal muscle. Similarity: Belongs to the tropomodulin family. Database links: Entrez Gene: 29765 Human Omim: 605834 Human SwissProt: Q9NZQ9 Human Unigene: 709681 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
