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Rabbit Anti-Histone H2A.V/Cy7 Conjugated antibody (bs-17425R-Cy7)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-17425R-Cy7
英文名稱1 Rabbit Anti-Histone H2A.V/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的組蛋白H2家族A.V抗體
別    名 H2A.F/Z; h2afv; H2AV; H2AV_HUMAN; Histone H2A.V.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Xenopus laevis)
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Histone H2A.V
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms a heterodimer with H2B (By similarity).

Subcellular Location:
Nucleus. Chromosome.

Post-translational modifications:
Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.

Similarity:
Belongs to the histone H2A family.

Database links:

Entrez Gene: 613618 Cow

Entrez Gene: 94239 Human

Entrez Gene: 77605 Mouse

Entrez Gene: 100328558 Rabbit

Entrez Gene: 444541 Xenopus laevis

Entrez Gene: 548932 Xenopus tropicalis

Entrez Gene: 252913 Zebrafish

SwissProt: Q32LA7 Cow

SwissProt: Q71UI9 Human

SwissProt: Q3THW5 Mouse

SwissProt: O62695 Rabbit

SwissProt: Q6GM74 Xenopus laevis

SwissProt: Q5BJ65 Xenopus tropicalis

SwissProt: Q71PD7 Zebrafish

Unigene: 488189 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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