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Rabbit Anti-OSGEP/BF555 Conjugated antibody (bs-17526R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17526R-BF555
英文名稱1 Rabbit Anti-OSGEP/BF555 Conjugated antibody
中文名稱 BF555標記的O-唾液酸糖蛋白內肽酶抗體
別    名 FLJ20411; GCPL-1; GCPL1; hOSGEP; KAE1; O sialoglycoprotein endopeptidase; OSGEP; OSGEP_HUMAN; OSGEP1; Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; Probable O sialoglycoprotein endopeptidase; Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep; PRSMG1; Prsmg1/Gcpl1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OSGEP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
O-sialoglycoprotein endopeptidases cleave the polypeptide backbone of membrane glycoproteins that contain clusters of O-linked sialoglycans. Osgep (O-sialoglycoprotein endopeptidase), also known as GCPL1, is a 335 amino acid protein that is a member of the peptidase M22 family. Osgep specifically cleaves the 31-Arg-l-Asp-32 bond in glycophorin A, but it does not cleave desialylated glycoproteins, unglycosylated proteins or glycoproteins that are only N-glycosylated. Though ubiquitously expressed at low levels, highest levels of Osgep are found in liver, skeletal muscle and kidney. OSGEPL1, also known as Qri7, is a 414 amino acid protein that belongs to the KAE1/YgjD family and exists as three alternatively spliced isoforms. In tRNAs that have codons beginning with adenine, OSGEPL1 is required for the formation of a threonylcarbamoyl group on adenosine.

Function:
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

Tissue Specificity:
Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.

Similarity:
Belongs to the KAE1 / YgjD family.

Database links:

Entrez Gene: 55644 Human

Entrez Gene: 66246 Mouse

Entrez Gene: 290028 Rat

Omim: 610107 Human

SwissProt: Q9NPF4 Human

SwissProt: Q8BWU5 Mouse

SwissProt: Q9WVS2 Rat

Unigene: 525196 Human

Unigene: 274791 Mouse

Unigene: 27608 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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