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Rabbit Anti-ORAI3/RBITC Conjugated antibody (bs-18021R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18021R-RBITC
英文名稱1 Rabbit Anti-ORAI3/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的嗅覺受體AI3抗體
別    名 MGC13024; Orai 3; ORAI calcium release activated calcium modulator 3; Orai3; ORAI3_HUMAN; Protein orai 3; Protein orai-3; TMEM 142C; TMEM142C; Transmembrane protein 142C.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ORAI3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Orai3 (ORAI calcium release-activated calcium modulator 3), also known as TMEM142C (transmembrane protein 142C), is a 295 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai3 plays an important role in store-operated calcium (SOC) entry, a process involving Ca(2+) influx and replenishment of Ca(2+) stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca(2+) mobilizing agents. CRAC channels are responsible for mediating calcium influx in T cells and play an important role in the immune response. Orai3, specifically, also acts as a regulator or component of the nuclear import of transcription factor NFAT.

Function:
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Subunit:
Interacts with CRACR2A/EFCAB4B.

Subcellular Location:
Membrane.

Similarity:
Belongs to the Orai family.

Database links:

Entrez Gene: 93129 Human

Entrez Gene: 269999 Mouse

Entrez Gene: 309000 Rat

Omim: 610930 Human

SwissProt: Q9BRQ5 Human

SwissProt: Q6P8G8 Mouse

SwissProt: Q6AXR8 Rat

Unigene: 729239 Human

Unigene: 36852 Mouse

Unigene: 42186 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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