| 產(chǎn)品編號(hào) | bs-18021R-BF488 |
| 英文名稱1 | Rabbit Anti-ORAI3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的嗅覺(jué)受體AI3抗體 |
| 別 名 | MGC13024; Orai 3; ORAI calcium release activated calcium modulator 3; Orai3; ORAI3_HUMAN; Protein orai 3; Protein orai-3; TMEM 142C; TMEM142C; Transmembrane protein 142C. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ORAI3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Orai3 (ORAI calcium release-activated calcium modulator 3), also known as TMEM142C (transmembrane protein 142C), is a 295 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai3 plays an important role in store-operated calcium (SOC) entry, a process involving Ca(2+) influx and replenishment of Ca(2+) stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca(2+) mobilizing agents. CRAC channels are responsible for mediating calcium influx in T cells and play an important role in the immune response. Orai3, specifically, also acts as a regulator or component of the nuclear import of transcription factor NFAT. Function: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. Subunit: Interacts with CRACR2A/EFCAB4B. Subcellular Location: Membrane. Similarity: Belongs to the Orai family. Database links: Entrez Gene: 93129 Human Entrez Gene: 269999 Mouse Omim: 610930 Human SwissProt: Q9BRQ5 Human SwissProt: Q6P8G8 Mouse Unigene: 729239 Human Unigene: 36852 Mouse Unigene: 42186 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
