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Rabbit Anti-SPOPL/Cy5 Conjugated antibody (bs-17684R-Cy5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17684R-Cy5
英文名稱1 Rabbit Anti-SPOPL/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的SPOPL蛋白抗體
別    名 HIB homolog 2; SPOPL_HUMAN; Roadkill homolog 2; Speckle type POZ protein like.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPOPL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SPOPL is a 392 amino acid nuclear protein that may be involved in ubiquitination and proteasomal degradation processes. Belonging to the Tdpoz family, SPOPL contains one BTB (POZ) domain and one MATH domain. SPOPL forms a complex with a member of the cullin family. The gene that encodes SPOPL includes 71,768 bases, four transcripts and maps to the human chromosome 2q22.1. Chromosomal arm 2q22-23 has been identified as one of fifteen hot spots thought to be involved in head and neck squamous cell carcinoma (HNSCC). Chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.

Function:
SPOPL belongs to the Tdpoz family. It contains 1 BTB (POZ) domain and 1 MATH domain. In complex with a cullin SPOPL may act in ubiquitination and proteasomal degradation processes.

Subunit:
Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.

Subcellular Location:
Nuclear

Similarity:
Belongs to the Tdpoz family.
Contains 1 BTB (POZ) domain.
Contains 1 MATH domain.

Database links:

Entrez Gene: 339745 Human

Entrez Gene: 296532 Rat

SwissProt: Q6IQ16 Human

SwissProt: B2RZC7 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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