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Rabbit Anti-phospho-Moesin (Thr558)/PE-Cy5.5 Conjugated antibody (bs-17703R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-17703R-PE-Cy5.5
英文名稱1 Rabbit Anti-phospho-Moesin (Thr558)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的磷酸化膜突蛋白抗體
別    名 Moesin (phospho T558); p-Moesin (phospho T558); Membrane organizing extension spike protein; Membrane-organizing extension spike protein; MOES_HUMAN; Moesin; Moesin/anaplastic lymphoma kinase fusion protein; MSN; MSN/ALK fusion.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Moesin around the phosphorylation site of Thr558
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane.

Subcellular Location:
Cell membrane. Cytoplasm; cytoskeleton. Apical cell membrane. Cell projection; microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.

Tissue Specificity:
In all tissues and cultured cells studied.

Post-translational modifications:
Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.

Similarity:
Contains 1 FERM domain.

Database links:

Entrez Gene: 4478 Human

Entrez Gene: 17698 Mouse

Omim: 309845 Human

SwissProt: P26038 Human

SwissProt: P26041 Mouse

Unigene: 87752 Human

Unigene: 138876 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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