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Rabbit Anti-LRRK1/BF350 Conjugated antibody (bs-18418R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-18418R-BF350
英文名稱1 Rabbit Anti-LRRK1/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的富含亮氨酸重復(fù)絲氨酸/蘇氨酸蛋白激酶1抗體
別    名 KIAA1790; Leucine rich repeat serine/threonine protein kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK 1; Lrrk1; LRRK1_HUMAN; RIPK6; Roco1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  G蛋白偶聯(lián)受體  細(xì)胞分化  G蛋白信號  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 225kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LRRK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2,038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
Contains 4 ANK repeats.
Contains 13 LRR (leucine-rich) repeats.
Contains 1 protein kinase domain.
Contains 1 Roc domain.

Database links:

Entrez Gene: 79705 Human

Entrez Gene: 233328 Mouse

Entrez Gene: 308703 Rat

Omim: 610986 Human

SwissProt: Q38SD2 Human

SwissProt: Q3UHC2 Mouse

Unigene: 407918 Human

Unigene: 33284 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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