| 產(chǎn)品編號(hào) | bs-18712R-AP |
| 英文名稱1 | Rabbit Anti-MCAF2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的活化轉(zhuǎn)錄因子7相互作用蛋白2抗體 |
| 別 名 | 4930558K11Rik; Activating transcription factor 7-interacting protein 2; ATF7 interacting protein 2; Atf7ip2; BC018510; FLJ12668; Get 1; MBD1-containing chromatin-associated factor 2; MCAF2; MCAF2_HUMAN; MGC6783; OTTHUMP00000160168; Protein similar to MCAF2; PSM2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MCAF2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MCAF2 is a 682 amino acid nuclear protein that exists as two alternatively spliced isoforms. MCAF2 can act as either an activator or repressor, thereby modulating chromatin formation and/or transcription regulation by linking transcription factors to transcription apparatuses. A member of the MCAF family, MCAF2 contains one fibronectin type-III domain and is thought to form a complex with ESET and MBD1. The gene encoding MCAF2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity Subunit: Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1. Subcellular Location: Nucleus. Similarity: Belongs to the MCAF family. Contains 1 fibronectin type-III domain. Database links: Entrez Gene: 80063 Human Entrez Gene: 75329 Mouse Omim: 613645 Human SwissProt: Q5U623 Human SwissProt: Q3UL97 Mouse Unigene: 513343 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
