吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
亚洲AV无码一区东京热久久,无码人妻一区二区三区免费视频
Rabbit Anti-HDAC4 + 5 + 9/BF488 Conjugated antibody (bs-10763R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10763R-BF488
英文名稱1 Rabbit Anti-HDAC4 + 5 + 9/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的組蛋白去乙?;?+5+9抗體
別    名 AHO3; Antigen NY-CO-9; BDMR; HA6116; HD4; HD5; HD7; HD7b; HD9; HDAC; HDAC-4; HDACA; HDAC4; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDRP; Histone deacetylase 4; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; MITR; NY-CO-9; HDAC4_HUMAN; HDAC5_HUMAN; HDAC9_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119/122/111kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. HDAC5: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. HDAC9: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gi es a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and de elopmental e ents. Histone deacetylases act ia the formation of large multiprotein complexes. In ol ed in muscle maturation ia its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Subunit:
Interacts with HDAC7. Homodimer. Homodimerization ia its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B. Interacts with KDM5B. Interacts with MYOCD. Interacts with MORC2. Interacts with ANKRA2.

Subcellular Location:
HDAC4: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. HDAC5: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. HDAC9: Nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.
Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and pre ented by phosphorylation by CaMK4.

DISEASE:
Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, de elopmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.

Database links:

Entrez Gene: 10014 Human

Entrez Gene: 9734 Human

Entrez Gene: 9759 Human

Entrez Gene: 15184 Mouse

Entrez Gene: 208727 Mouse

Entrez Gene: 79221 Mouse

Entrez Gene: 314040 Rat

Entrez Gene: 363287 Rat

Entrez Gene: 84580 Rat

Omim: 605314 Human

Omim: 605315 Human

Omim: 606543 Human

SwissProt: P56524 Human

SwissProt: Q9UKV0 Human

SwissProt: Q9UQL6 Human

SwissProt: Q6NZM9 Mouse

SwissProt: Q99N13 Mouse

SwissProt: Q9Z2V6 Mouse

SwissProt: Q99P99 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲精品无码国产| 欧美大肥婆大肥BBBBB| 色哟哟网站在线观看| 小处雏一区二区三区精品视频| 欧美大肥婆大肥BBBBB| 两根硕大一起挤进小紧H共妻| 羞羞漫画在线观看| 亚洲成AV人片在线观看无 | 国产亚洲精品AAAA片小说| 18禁免费无码无遮挡不卡网站 | 成人毛片18女人毛片免费| 国产精品久久久久久麻豆一区| 亚洲午夜精品久久久久久浪潮| 无码人妻久久一区二区三区蜜桃| 久久99精品国产麻豆婷婷| 国产三级片在线观看| 国产一区二区精品久久| 小浪货腿张开水好多呀H| 能收黄台的APP不收费| 国产又猛又黄又爽| 亚洲AV无码一区二区三区性色| 男男车车的车车网站W98免费| 国产SUV精品一区二区| 国产精品久久久久9999| 午夜精品久久久久久久久| 青春草在线视频观看| 日本无码小泬粉嫩精品图| 精品欧美一区二区在线观看| 中文资源在线官网| 欧美激情综合色综合啪啪五月 | 欧美亚洲色综久久精品国产| 欧美疯狂做受XXXXX高潮| 18video性欧美19sex高清| 少妇无码一区二区三区免费| 欧美成人片一区二区三区 | 久久精品国产精品亚洲精品| 全部孕妇毛片丰满孕妇孕交| 无码人妻久久一区二区三区蜜桃 | 和山田进行LV999的恋爱| 亚洲成熟丰满熟妇高潮XXXXX| 欧美精品视频|