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Rabbit Anti-CCL27/BF488 Conjugated antibody (bs-20841R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-20841R-BF488
英文名稱1 Rabbit Anti-CCL27/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的皮膚T細(xì)胞虜獲趨化因子抗體
別    名 ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  趨化因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CCL27
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].

Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

Subcellular Location:
Secreted.

Tissue Specificity:
Testis, thymus, placenta, ovary and skin.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Database links:

Entrez Gene: 100039863 Mouse

Entrez Gene: 100039939 Mouse

Entrez Gene: 100040048 Mouse

Entrez Gene: 20301 Mouse

Entrez Gene: 362505 Rat

SwissProt: Q9Z1X0 Mouse

Unigene: 335946 Mouse

Unigene: 425176 Mouse

Unigene: 484274 Mouse

Unigene: 6660 Mouse

Unigene: 78371 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CCL27是一種CC型趨化因子,又被稱為Skinkine,ESkine和CTACK。CCL27基因位于人類染色體9,它與皮膚上歸巢的記憶T淋巴細(xì)胞有關(guān),并在T細(xì)胞介導(dǎo)的皮膚炎癥中起著重要的作用。CCL27表達(dá)在許多組織,包括性腺,胸腺,胎盤和皮膚。其配體為CCR10,CCL27與接觸性軟疣病毒編碼產(chǎn)生的蛋白質(zhì)MC148有較高的同源性,但卻與人皰疹病毒8型編碼產(chǎn)生病毒巨噬細(xì)胞炎癥蛋白-Ⅱ競爭結(jié)合受體CCR10。
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