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Rabbit Anti-TM2D1/FITC Conjugated antibody (bs-19942R-FITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19942R-FITC
英文名稱1 Rabbit Anti-TM2D1/FITC Conjugated antibody
中文名稱 FITC標記的β淀粉樣蛋白結合蛋白抗體
別    名 BBP; Beta amyloid binding protein; hBBP; TM2 domain containing 1; TM2 domain containing protein 1; TM2D1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  細胞凋亡  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TM2D1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]

Function:
May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.

Subunit:
Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the TM2 family.

Database links:

Entrez Gene: 83941 Human

Entrez Gene: 94043 Mouse

Entrez Gene: 362545 Rat

Omim: 610080 Human

SwissProt: Q9BX74 Human

SwissProt: Q99MB3 Mouse

Unigene: 656790 Human

Unigene: 331719 Mouse

Unigene: 198278 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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