吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产又色又爽又高潮免费,欧美精产国品一二三产品区别在哪 ,国产精品日日做人人爱
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-DRP1 (Ser616)/PE-Cy7 Conjugated antibody (bs-12702R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12702R-PE-Cy7
英文名稱1 Rabbit Anti-phospho-DRP1 (Ser616)/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的磷酸化動力相關(guān)蛋白1抗體
別    名 DRP1 (phospho S616); p-DRP1 (phospho S616); P-DRP1 (Ser616); DLP1; dnm1l; DNM1L_HUMAN; Dnm1p/Vps1p-like protein; DVLP; Dymple; Dynamin 1 like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin like protein; Dynamin related protein 1; Dynamin-1-like protein; Dynamin-like protein 4; Dynamin-like protein; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV 11; FLJ41912; HdynIV; VPS1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導(dǎo)  細胞凋亡  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Guinea Pig, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human DRP1 around the phosphorylation site of Ser616
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Function:
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport.
Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Subcellular Location:
Cytoplasm > cytosol. Golgi apparatus. Endomembrane system. Mainly cytosolic. Translocated to the mitochondrial membrane through interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex.

Tissue Specificity:
Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons.

Post-translational modifications:
Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission. Phosphorylation on Ser-637 inhibits mitochondrial fissin probably through preventing intramolecular interaction. Dephosphorylated on this site by PPP3CA which promotes mitochondrial fission. Phosphorylation on Ser-616 also promotes mitochondrial fission.
Sumoylated on various lysine residues within the B domain. Desumoylated by SENP5 during G2/M transition of mitosis. Appears to be linked to its catalytic activity.
S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage.
Ubiquitination by MARCH5 affects mitochondrial morphology.

DISEASE:
Note=May be associated with Alzheimer disease through beta-amyloid-induced increased S-nitrosylation of DNM1L, which triggers, directly or indirectly, excessive mitochondrial fission, synaptic loss and neuronal damage.

Similarity:
Belongs to the dynamin family.
Contains 1 GED domain.

Database links:

Entrez Gene: 10059 Human

Entrez Gene: 74006 Mouse

Entrez Gene: 114114 Rat

Omim: 603850 Human

SwissProt: O00429 Human

SwissProt: Q8K1M6 Mouse

SwissProt: O35303 Rat

Unigene: 556296 Human

Unigene: 218820 Mouse

Unigene: 216851 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久精品国产亚洲AV麻豆色欲| 久久99精品国产麻豆不卡| 精品久久人妻AV中文字幕| 97成人无码免费一区二区中文| 欧美性色黄大片A级毛片视频| 国产日产亚洲系列最新| 免费无遮挡无码永久在线观看视频| 好爽…又高潮了免费毛片| 被老外做的下身都肿了| 亚洲色无码A片一区二小说| 亚VA芒果乱码一二三四区别| 人妻互换精品一区二区| 少妇被多人C夜夜爽爽AV| 国产精品爽黄69天堂A片| 少妇愉情理伦片高潮日本| 人妻无码一区二区三区| 亚洲AV无码片VR一区二区三区| 又湿又紧又大又爽A视频| 国产成人精品无码一区二区| 国产成人午夜精品久久久久久| 亚洲国产精品久久久久秋霞影院| 隔着内裤揉搓她的花蒂H漫画| 俄罗斯大荫蒂女人毛茸茸| JAPAN丰满人妻HDXXXX| 久久久久99人妻一区二区三区| 精品一区二区三区免费视频| 国自产拍偷拍精品啪啪模特| 国产精品人人做人人爽人人添| 国产精品久久久久9999| 高清VPSWINDOWS另类乱| 亚洲精品乱码久久久久蜜桃| 在线观看的AV网站| 亚洲精品无码久久久久 | 国产AV无码专区亚洲A∨毛片| 久久免费看少妇高潮V片特黄| 真人实拍女处被破WWW免费| 99精品国产一区二区| 无码人妻精品一区二区蜜桃网站| 四虎影视在线影院在线观看| 久久人人97超碰A片精品| 99久久无码一区人妻A片|