吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产精品丝袜久久久久久不卡 ,少妇无码一区二区二三区,特大黑人与亚洲娇小
Rabbit Anti-SATB1/BF350 Conjugated antibody (bs-20148R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@xucheq.com
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-20148R-BF350
英文名稱1 Rabbit Anti-SATB1/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的核基質(zhì)結(jié)合區(qū)結(jié)合蛋白1抗體
別    名 DNA binding protein SATB1; DNA-binding protein SATB1; SATB homeobox 1; SATB1; SATB1_MOUSE; Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA); Special AT rich sequence binding protein 1; Special AT-rich sequence-binding protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號  結(jié)合蛋白  新陳代謝  線粒體  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SATB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Function:
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.

Subunit:
Interacts with PCAF. Interacts with sumoylated PML and HDAC1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300. Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA.

Subcellular Location:
Nucleus. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Tissue Specificity:
Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain.

Post-translational modifications:
Sumoylated. Sumoylation promotes cleavage by caspases.
Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association.

Similarity:
Belongs to the CUT homeobox family.
Contains 2 CUT DNA-binding domains.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 6304 Human

Entrez Gene: 20230 Mouse

Omim: 602075 Human

SwissProt: Q01826 Human

SwissProt: Q60611 Mouse

Unigene: 517717 Human

Unigene: 311655 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
波多野结衣绝顶大高潮| 国产精品美女午夜爽爽爽免费| 青青草原精品99久久精品66| AV无码精品一区二区三区四区| 久久久久无码专区亚洲AV| AV免费网站在线观看| 免费a级毛片在线播放| 国产特黄级AAAAA片免| 日本护士毛茸茸| 又大又紧又粗C欧美成人在线视频| 狠狠色综合7777久夜色撩人,| 亚洲AV日韩AV无码污污网站| 啊轻点灬太粗嗯太深了用力 | 隔着内裤揉搓她的花蒂H漫画| 国产午夜精品一区二区三区 | 久久久久国产精品| 欧美AV在线观看| 免费AV一区二区三区| 国产精品第一页| 全免费A级毛片免费看| 国产chinasex对白videos麻豆| 国产福利视频在线观看| 国产成人精品一区二区三区视频| 精品人伦一区二区三区蜜桃小说| 性色av无码| 女人下部毛毛高清| 荫蒂每天被男人添| A片做爰片仑理片免费看午夜蝴蝶 久久久久久国产精品免费免费 | 午夜福利一区二区三区在线观看 | 宝贝你的奶好大我想吃第一章| 精品人妻人人做人人爽夜夜爽| 少妇久久久久久久久久| 久久AV高潮AV无码AV喷吹| 久久精品国产精品亚洲毛片 | 国内老熟妇对白HDXXXX| 日韩无码电影| 亚洲H在线播放在线观看H | 亚洲成色WWW久久网站| 国产+日韩+另类+视频一区| 6080YYY午夜理论片中无码| 两个人在线观看视频|