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Rabbit Anti-VGLUT3/SLC17A8/RBITC Conjugated antibody (bs-8701R-RBITC)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-8701R-RBITC
英文名稱1 Rabbit Anti-VGLUT3/SLC17A8/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的囊泡谷氨酸轉(zhuǎn)運(yùn)蛋白3抗體
別    名 deafness autosomal dominant 25; DFNA 25; DFNA25; SLC17A8; Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) member 8; Solute carrier family 17 member 8; Vesicular glutamate transporter 3; VGLU3_HUMAN; VGLUT 3; VGluT3.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  轉(zhuǎn)運(yùn)蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VGLUT3/SLC17A8
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Subcellular Location:
Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Membrane. Cell junction > synapse > synaptosome.

Tissue Specificity:
Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.

DISEASE:
Defects in SLC17A8 are the cause of deafness autosomal dominant type 25 (DFNA25) [MIM:605583]. DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.

Similarity:
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Database links:

Entrez Gene: 246213 Human

Entrez Gene: 216227 Mouse

Entrez Gene: 266767 Rat

Omim: 607557 Human

SwissProt: Q8NDX2 Human

SwissProt: Q8BFU8 Mouse

SwissProt: Q7TSF2 Rat

Unigene: 116871 Human

Unigene: 233921 Mouse

Unigene: 84876 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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