| 產(chǎn)品編號(hào) | bsm-33263M-AP |
| 英文名稱1 | Mouse Anti-PPAR delta/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的D型-過氧化酶活化增生受體單克隆抗體 |
| 別 名 | FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 免疫學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | 4H10 |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human PPAR delta Protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 儲(chǔ) 存 液 | Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體（Steroid Receptors） 研究人員指出該分子的功能，極可能就是阻斷心血管免疫發(fā)炎反應(yīng)的訊號(hào)傳遞過程。PPAR－delta基因是控制肌肉發(fā)展的重要基因，在增加老鼠耐力的同時(shí)還能幫助它燃燒掉脂肪，研究人員發(fā)現(xiàn)，對于與新陳代謝有關(guān)的各項(xiàng)疾病，從心臟病到肥胖癥都有啟發(fā)性的意義，他可以阻止脂肪沉淀在動(dòng)脈壁上，進(jìn)而防止動(dòng)脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動(dòng)脈硬化和癌癥的發(fā)病。 在動(dòng)脈硬化現(xiàn)象發(fā)生的早期，免疫細(xì)胞會(huì)促使血管慢性的發(fā)炎，因而造成血管不斷地吸收和輸送脂肪，進(jìn)而導(dǎo)致脂肪的堆積與血管硬化，而PPAR-delta就像警衛(wèi)分子一樣，時(shí)時(shí)降低發(fā)炎反應(yīng)和抑制動(dòng)脈硬化斑的形成，因此該分子應(yīng)該是相關(guān)藥物研發(fā)，相當(dāng)值得切入的目標(biāo)。 研究人員認(rèn)為，這個(gè)發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。 |
