產(chǎn)品編號 | bsm-33263M-PE-Cy5 |
英文名稱1 | Mouse Anti-PPAR delta/PE-Cy5 Conjugated antibody |
中文名稱 | PE-Cy5標記的D型-過氧化酶活化增生受體單克隆抗體 |
別 名 | FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領域 | 心血管 免疫學 |
抗體來源 | Mouse |
克隆類型 | Monoclonal |
克 隆 號 | 4H10 |
交叉反應 | (predicted: Human, Mouse, Rat, ) |
產(chǎn)品應用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 48kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | Recombinant human PPAR delta Protein |
亞 型 | IgG |
純化方法 | affinity purified by Protein G |
儲 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體(Steroid Receptors) 研究人員指出該分子的功能,極可能就是阻斷心血管免疫發(fā)炎反應的訊號傳遞過程。PPAR-delta基因是控制肌肉發(fā)展的重要基因,在增加老鼠耐力的同時還能幫助它燃燒掉脂肪,研究人員發(fā)現(xiàn),對于與新陳代謝有關的各項疾病,從心臟病到肥胖癥都有啟發(fā)性的意義,他可以阻止脂肪沉淀在動脈壁上,進而防止動脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動脈硬化和癌癥的發(fā)病。 在動脈硬化現(xiàn)象發(fā)生的早期,免疫細胞會促使血管慢性的發(fā)炎,因而造成血管不斷地吸收和輸送脂肪,進而導致脂肪的堆積與血管硬化,而PPAR-delta就像警衛(wèi)分子一樣,時時降低發(fā)炎反應和抑制動脈硬化斑的形成,因此該分子應該是相關藥物研發(fā),相當值得切入的目標。 研究人員認為,這個發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。 |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關于肽鏈的設計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |