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Mouse Anti-PPAR delta/BF488 Conjugated antibody (bsm-33263M-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-33263M-BF488
英文名稱1 Mouse Anti-PPAR delta/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的D型-過氧化酶活化增生受體單克隆抗體
別    名 FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 4H10
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human PPAR delta Protein
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.

Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous with maximal levels in placenta and skeletal muscle.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 5467 Human

Entrez Gene: 19015 Mouse

Entrez Gene: 25682 Rat

Omim: 600409 Human

SwissProt: Q03181 Human

SwissProt: P35396 Mouse

Unigene: 696032 Human

Unigene: 328914 Mouse

Unigene: 96181 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

類固醇受體(Steroid Receptors)
研究人員指出該分子的功能,極可能就是阻斷心血管免疫發(fā)炎反應(yīng)的訊號傳遞過程。PPAR-delta基因是控制肌肉發(fā)展的重要基因,在增加老鼠耐力的同時還能幫助它燃燒掉脂肪,研究人員發(fā)現(xiàn),對于與新陳代謝有關(guān)的各項疾病,從心臟病到肥胖癥都有啟發(fā)性的意義,他可以阻止脂肪沉淀在動脈壁上,進而防止動脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動脈硬化和癌癥的發(fā)病。
在動脈硬化現(xiàn)象發(fā)生的早期,免疫細(xì)胞會促使血管慢性的發(fā)炎,因而造成血管不斷地吸收和輸送脂肪,進而導(dǎo)致脂肪的堆積與血管硬化,而PPAR-delta就像警衛(wèi)分子一樣,時時降低發(fā)炎反應(yīng)和抑制動脈硬化斑的形成,因此該分子應(yīng)該是相關(guān)藥物研發(fā),相當(dāng)值得切入的目標(biāo)。
研究人員認(rèn)為,這個發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。
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