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Rabbit Anti-Phospho-MKP1 (Ser296)/PE-Cy5 Conjugated antibody (bs-23272R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23272R-PE-Cy5
英文名稱1 Rabbit Anti-Phospho-MKP1 (Ser296)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的磷酸化絲裂原活化蛋白激酶磷酸酶-1抗體
別    名 DUSP1 (phospho S296); MKP1 (Phospho Ser296); MKP1 (Phospho S296); Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUSP 1; EC 3.1.3.16; EC 3.1.3.48; HVH 1; HVH1; MAP kinase phosphatase 1; MKP 1; MKP1; MKP-1; Protein tyrosine phosphatase CL100; PTPN 10; PTPN10; Serine/threonine specific protein phosphatase; VH 1; VH1; 3ch134; Mkp1; Ptpn16.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Phospho-MKP1 (Ser296)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.

Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185'.

Tissue Specificity:
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 1843 Human

Entrez Gene: 19252 Mouse

Entrez Gene: 114856 Rat

Omim: 600714 Human

SwissProt: P28562 Human

SwissProt: P28563 Mouse

SwissProt: Q64623 Rat

Unigene: 171695 Human

Unigene: 239041 Mouse

Unigene: 98260 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MKPs是一類(lèi)絲氨酸/蘇氨酸和酪氨酸雙重底物特異性的磷酸酶 ,對(duì)于絲裂素活化蛋白激酶活性的調(diào)節(jié)起著十分重要的作用,可使絲裂素活化蛋白激酶上的蘇氨酸/酪氨酸去磷酸化失活。目前研究發(fā)現(xiàn)MKPs分別有MKP-1、MKP-2、MKP-3及MKP4-6。
MKPs受MAPK信號(hào)通路中多種成分的誘導(dǎo) ,決定了它與MAPK之間作用的特異性。 通過(guò)去磷酸化作用調(diào)節(jié)MAPK信號(hào)途徑的活性 ,確保了細(xì)胞內(nèi)信號(hào)的精確傳遞 ,參與了多種主要的細(xì)胞功能的調(diào)節(jié)。
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