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Rabbit Anti-CD63/APC Conjugated antibody (bs-23032R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23032R-APC
英文名稱1 Rabbit Anti-CD63/APC Conjugated antibody
中文名稱 APC標(biāo)記的黑色素瘤相關(guān)抗原抗體
別    名 Lysosomal associated membrane protein 3; CD63 antigen; CD63 antigen melanoma 1 antigen; CD63 molecule; granulophysin; LAMP 3; LAMP3; lysosome associated membrane glycoprotein 3; CD 63; CD63; CD63 antigen (melanoma 1 antigen); CD63_HUMAN; gp55; granulophysin; LAMP-3; LIMP; Lysosomal-associated membrane protein 3; Melanoma-associated antigen ME491; NGA; Ocular melanoma-associated antigen; PTLGP40; Tetraspanin-30; Tspan-30; Mast cell antigen AD1; ME491; melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; MGC72893; MLA 1; MLA1; ocular melanoma associated antigen; OMA81H; Tetraspanin 30; Tspan 30; TSPAN30; Tumor biomarkers; Platelets markers.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CD63
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.

Function:
This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules.

Tissue Specificity:
Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

Database links:

Entrez Gene: 404156 Cow

Entrez Gene: 967 Human

Entrez Gene: 12512 Mouse

Entrez Gene: 100008988 Rabbit

Omim: 155740 Human

SwissProt: Q9XSK2 Cow

SwissProt: P08962 Human

SwissProt: P41731 Mouse

SwissProt: Q28709 Rabbit

Unigene: 445570 Human

Unigene: 371552 Mouse

Unigene: 416079 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD63為溶酶體膜糖蛋白也是一種細(xì)胞表面糖蛋白,可表達(dá)在多種細(xì)胞的表面和胞漿內(nèi),血小板活化后即轉(zhuǎn)移至膜表面。
CD63—又稱黑色素瘤相關(guān)抗原MLA1和整合素形成復(fù)合物。是血液血小板活化的標(biāo)志。與一些腫瘤的進(jìn)展也有關(guān)聯(lián)。
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