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Rabbit Anti-CD9/BF594 Conjugated antibody (bs-23035R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23035R-BF594
英文名稱1 Rabbit Anti-CD9/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的CD9蛋白抗體
別    名 Tetraspanin 29; 5H9; 5H9 antigen; Antigen defined by monoclonal; 602 29; Antigen defined by monoclonal; 60229; BA 2; BA2; BTCC 1; BTCC1; CD 9; CD9; CD9 antigen; CD9 antigen p24; CD9 molecule; CD9_HUMAN; Cell growth inhibiting gene 2 protein; Cell growth-inhibiting gene 2 protein; DRAP 27; DRAP27; GIG 2; GIG2; Growth inhibiting gene 2 protein; Leukocyte antigen MIC3; MIC 3; MIC3; Motility related protein; Motility-related protein; MRP 1; MRP-1; MRP1; p24; P24; p24 antigen; Tetraspanin 29; Tetraspanin-29; Tetraspanin29; Tspan 29; Tspan-29; Tspan29.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD9
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve.

Function:
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Subunit:
Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed by a variety of hematopoietic and epithelial cells.

Post-translational modifications:
Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

Database links:

Entrez Gene: 928 Human

Entrez Gene: 12527 Mouse

Entrez Gene: 24936 Rat

Omim: 143030 Human

SwissProt: P21926 Human

SwissProt: P40240 Mouse

SwissProt: P40241 Rat

Unigene: 114286 Human

Unigene: 210676 Mouse

Unigene: 404614 Mouse

Unigene: 2091 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD9是一種普遍存在于細(xì)胞膜表面屬于四跨膜超蛋白家族的細(xì)胞表面糖蛋白, 參與質(zhì)膜的融合過程,在細(xì)胞膜生物學(xué)中發(fā)揮重要作用。
近年來經(jīng)研究發(fā)現(xiàn),CD9與多種腫瘤轉(zhuǎn)移有關(guān),故稱腫瘤轉(zhuǎn)移抑制基因亦稱抗腫瘤轉(zhuǎn)移基因。是一個(gè)新的腫瘤轉(zhuǎn)移抑制基因膜運(yùn)動(dòng)相關(guān)蛋白-1(CD9/MRP-1),其分子功能還有待于進(jìn)一步研究。CD9主要在早B細(xì)胞、活化T淋巴細(xì)胞、嗜酸性粒細(xì)胞、嗜堿性粒細(xì)胞和血小板表達(dá)。
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