吃奶呻吟打开双腿做受动态图 -亚洲色偷偷色噜噜狠狠99网-日韩精品极品视频在线观看免费-来一水AV@lysav

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产精品无码久久久久,成人午夜亚洲精品无码网站
Rabbit Anti-CD163/Cy3 Conjugated antibody (bs-23127R-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@xucheq.com
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@xucheq.com
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23127R-Cy3
英文名稱1 Rabbit Anti-CD163/Cy3 Conjugated antibody
中文名稱 Cy3標(biāo)記的CD163抗體
別    名 Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 121kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD163
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.

Function:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Subcellular Location:
Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Tissue Specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Post-translational modifications:
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.

Similarity:
Contains 9 SRCR domains.

Database links:

Entrez Gene: 9332 Human

Entrez Gene: 93671 Mouse

Entrez Gene: 312701 Rat

Omim: 605545 Human

SwissProt: Q86VB7 Human

SwissProt: Q2VLH6 Mouse

Unigene: 504641 Human

Unigene: 37426 Mouse

Unigene: 203204 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD163是SRCR超家族成員之一,又稱為血紅蛋白清道夫受體(hemoglobin scavenger receptor, HbSR)、M130或p155。CD163的表達(dá)水平受很多因素調(diào)節(jié),糖皮質(zhì)激素及抗炎介質(zhì)如IL-10以及IL-6能上調(diào)CD163, 而促炎介質(zhì)如脂多糖(lipopolysaccharide, LPS)、γ-干擾素(interferon-γ, IFN-γ)以及TNF-α則抑制CD163表達(dá)。 CD163是一種I型膜蛋白,又稱為M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表達(dá)于單核/巨噬細(xì)胞系,所有循環(huán)系統(tǒng)的單核細(xì)胞和大多數(shù)組織(除外淋巴濾泡套區(qū)和生發(fā)中心)的巨噬細(xì)胞均陽(yáng)性表達(dá),主要用于單核/巨噬細(xì)胞的檢測(cè)。
版權(quán)所有 2004-2026 www.xucheq.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
公和我在野外做好爽爱爱小说雨婷| 国产精品污WWW在线观看| 亚州av| 少妇AV射精精品蜜桃专区| 我把五十老女人弄高潮了| 少妇无码一区二区三区| 国产,日韩,丝袜,欧美一区| 在教室伦流澡到高潮HGL视频| 人人妻人人玩人人澡人人爽| 精品国产一区二区三区无码| 玩弄白嫩少妇XXXXX性| 亚洲乱码一区AV春药高潮| 亚洲乱码日产精品BD在线观看 | 扒开腿狂躁女人爽出白浆| 久久久久久亚洲AV无码专区| 挺进邻居丰满少妇的身体| 日本人妻丰满熟妇久久久久久| 天堂А√在线中文在线新版| 高清在线播放| 亚洲AV成人片无码| 国产激情无码一区二区三区| 粉嫩小泬无遮挡久久久久久| 成人免费视频在线观看| 亚洲AV乱码久久精品蜜桃| 久久亚洲AV成人无码国产| 亚洲欧美乱综合图片区小说区| 啦啦啦WWW日本高清免费观看| 学长被C哭着爬走又被拉回来 | 亚洲精品国偷拍自产在线观看蜜臀| 亚洲国产精品无码中文在线 | 天堂资源最新在线| 久久久久亚洲AV无码A片下载| 99亚洲狠狠色综合久久位| 亚洲国产精品无码成人片久久 | 久久久婷婷五月亚洲97号色| 欧美老熟妇乱大交XXXXX| 蜜臀av国产精品久久久久| 3D动漫精品啪啪一区二区免费| 国产成人久久精品激情| 国产亚州精品女人久久久久久| 隔壁人妻偷人BD中字 |