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Mouse Anti-CD2/Gold Conjugated antibody (bsm-33075M-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-33075M-Gold
英文名稱1 Mouse Anti-CD2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的CD2單克隆抗體
別    名 T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11/Leu 5; T11; CD2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  細(xì)胞表面分子  t-淋巴細(xì)胞  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 5H3
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD2
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes.
CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.

Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Subunit:
Interacts with CD2AP. Interacts with PSTPIP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 914 Human

Entrez Gene: 12481 Mouse

Entrez Gene: 497761 Rat

Omim: 186990 Human

SwissProt: P06729 Human

SwissProt: P08920 Mouse

SwissProt: P08921 Rat

Unigene: 523500 Human

Unigene: 22842 Mouse

Unigene: 10328 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD2分子又稱T11、綿羊紅細(xì)胞受體(ER)、淋巴細(xì)胞功能相關(guān)抗原2(LFA-2)和Leu5,是人T淋巴細(xì)胞表面的單鏈糖蛋白.CD2分子是分布于胸腺細(xì)胞及所有成熟T淋巴細(xì)胞和大部分自然殺傷細(xì)胞表面的特征性分化抗原。CD2具有調(diào)節(jié)T淋巴細(xì)胞分化、成熟、激活和凋亡等功能,CD2與LFA-3之間的粘附功能對(duì)于T淋巴細(xì)胞TCR識(shí)別外來抗原與APC細(xì)胞表面MHC抗原復(fù)合物、腫瘤抗原、病毒感染靶細(xì)胞以及同種異體抗原均有重要的輔助作用。
最近研究表明,CD48和CD59也是CD2的配體,參與T細(xì)胞的粘附和細(xì)胞間的相互作用,此外,CD2可以與其它膜分子如CD44、CD45的功能有關(guān)。CD2具有對(duì)T細(xì)胞的旁路激活途徑作用。
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