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Mouse Anti-GAP43/RBITC Conjugated antibody (bsm-33192M-RBITC)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-33192M-RBITC
英文名稱1 Mouse Anti-GAP43/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的神經(jīng)生長(zhǎng)相關(guān)蛋白43單克隆抗體
別    名 Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 6F11
交叉反應(yīng) Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human GAP43 Protein
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Subunit:
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Post-translational modifications:
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

Similarity:
Belongs to the neuromodulin family.
Contains 1 IQ domain.

Database links:

Entrez Gene: 2596 Human

Entrez Gene: 14432 Mouse

Entrez Gene: 29423 Rat

GenBank: NP_002036 Human

Omim: 162060 Human

SwissProt: P17677 Human

SwissProt: P06837 Mouse

SwissProt: P07936 Rat

Unigene: 134974 Human

Unigene: 1222 Mouse

Unigene: 10928 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology);神經(jīng)標(biāo)志物
GAP43 (Growth associated protein-43)又稱作neuromodulin,是一個(gè)軸突膜蛋白,是一種神經(jīng)特異性的蛋白質(zhì),參與神經(jīng)細(xì)胞外生長(zhǎng)及突觸發(fā)育形成和神經(jīng)細(xì)胞再生。在神經(jīng)元發(fā)育和再生過(guò)程中以高水平表達(dá)。能調(diào)解軸突延伸作用,改變細(xì)胞形態(tài)。作為細(xì)胞內(nèi)信號(hào),可大大增強(qiáng)與G蛋白偶聯(lián)的受體轉(zhuǎn)運(yùn)作用。
神經(jīng)生長(zhǎng)相關(guān)蛋白-GAP-43和神經(jīng)細(xì)胞黏附因子(neural cell adhesion molecule,NCAM)與突觸可塑性密切相關(guān).GAP-43是一種神經(jīng)細(xì)胞膜上的特異性磷蛋白,在神經(jīng)發(fā)育和再生過(guò)程中呈現(xiàn)高表達(dá),被作為突觸生長(zhǎng)的標(biāo)志物,有稱脊髓生長(zhǎng)相關(guān)蛋白
GAP-43與CaM結(jié)合,參與G蛋白相互作用,神經(jīng)遞質(zhì)的釋放,作用于胞吞/胞吐過(guò)程,通過(guò)小囊溶合或誘導(dǎo)生長(zhǎng)錐和突觸前末端的胞吞促進(jìn)膜擴(kuò)展,與海馬長(zhǎng)時(shí)程增強(qiáng)密切相關(guān).
神經(jīng)細(xì)胞黏附因子是細(xì)胞表面糖蛋白大家族的成員之一,促進(jìn)軸突生長(zhǎng),對(duì)長(zhǎng)時(shí)記憶的保持有重要影響,同時(shí),GAP-43對(duì)其具調(diào)節(jié)作用,廣泛而深入地研究GAP-43意義深遠(yuǎn)。
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